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AOD-9604 is an intellectually interesting compound whose mechanism is well-characterized in preclinical models, whose safety profile is genuinely clean, and whose clinical program ultimately did not deliver

Experimental and animal studies demonstrated that the downstream products of vitamin B12 metabolism are increased and oxidative stress, steatosis, and fibrosis develop in the liver in cystathionine -synthase-deficient mice (57)

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and accelerated matrix remodeling through coordinated MMP activity and collagen deposition

Failed septic systems are affecting the quality of life of Navajo people and will continue to impact the health of the community, particularly for children and the elderly residents who are the most vulnerable